MEMORANDUM **
California state prisoner Ricardo Guzman appeals pro se from the district court’s judgment dismissing his 42 U.S.C. § 1983 action alleging, among other things, deliberate indifference to a serious medical need. We have jurisdiction under 28 U.S.C. § 1291. We review de novo the district court’s dismissal under 28 U.S.C. § 1915A. Hamilton v. Brown, 630 F.3d 889, 892 (9th Cir.2011). We affirm.
The district court properly dismissed Guzman’s claim because Guzman failed to allege facts sufficient to show that defendants acted with deliberate indifference in performing his liver biopsy and treating his post-biopsy pain and injury. See Toguchi v. Chung, 391 F.3d 1051, 1057-58 (9th Cir.2004) (a prison official acts with deliberate indifference only if the prison official knows of and disregards an excessive risk to the prisoner’s health; medical malpractice, negligence, or a mere difference of opinion concerning the course of treatment is insufficient); see also Hebbe v. Pliler, 627 F.3d 338, 341-42 (9th Cir.2010) (although- pro se pleadings are liberally construed, a plaintiff must allege facts sufficient to state a plausible claim).
The district court did not abuse its discretion by denying leave to amend after providing one opportunity to amend and concluding that further amendment would be futile. See Lopez v. Smith, 203 F.3d 1122, 1130 (9th Cir.2000) (en banc) (setting forth standard of review and explaining that leave to amend should be given unless the deficiencies in the complaint cannot be cured by amendment); see also Ferdik v. *330Bonzelet, 968 F.2d 1258, 1261 (9th Cir. 1992) (the district court’s discretion to deny leave to amend is particularly broad where it has afforded plaintiff one or more opportunities to amend).
AFFIRMED.